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- | ====== XopAD ====== | ||
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- | Author: [[https:// | ||
- | Internal reviewer: [[https:// | ||
- | Expert reviewer: FIXME | ||
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- | Class: XopAD\\ | ||
- | Family: XopAD\\ | ||
- | Prototype: XopAD (// | ||
- | RefSeq ID: not found in RefSeq. GenBank accession: [[https:// | ||
- | 3D structure: Unknown | ||
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- | ===== Biological function ===== | ||
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- | === How discovered? === | ||
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- | XopAD was discovered using a machine-learning approach (Teper //et al//., 2016). | ||
- | === (Experimental) evidence for being a T3E === | ||
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- | XopAD fused to the AvrBs2 reporter domain, was shown to translocate into plant cells in an // | ||
- | === Regulation === | ||
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- | No PIP box was found in the promoter region of //xopAD// in //X. euvesicatoria// | ||
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- | qRT-PCR revealed that transcript levels of 15 out of 18 tested non-TAL effector genes (as well as the regulatory genes //hrpG// and //hrpX//), including //xopAD//, were significantly reduced in the // | ||
- | === Phenotypes === | ||
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- | Deletion of //xopAD// does not alter //X. citri// pv. //citri// (//Xci//) pathogenicity (Escalon //et al//., 2013). | ||
- | === Localization === | ||
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- | Unknown. | ||
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- | === Enzymatic function === | ||
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- | Not known. However, the 614 amino acid protein consists of multiple [[https:// | ||
- | === Interaction partners === | ||
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- | Not known. | ||
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- | ===== Conservation ===== | ||
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- | === In xanthomonads === | ||
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- | Yes. XopAD has homologues encoded in the genomes of most // | ||
- | === In other plant pathogens/ | ||
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- | Yes. XopAD is homologous to members of the RipS1 family of effectors in //Ralstonia solanacearum// | ||
- | ===== References ===== | ||
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- | Escalon A, Javegny S, Vernière C, Noël LD, Vital K, Poussier S, Hajri A, Boureau T, Pruvost O, Arlat M, Gagnevin L (2013). Variations in type III effector repertoires, | ||
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- | Harrison J, Studholme DJ (2014). Draft genome sequence of // | ||
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- | Liu Y, Long J, Shen D, Song C (2016). // | ||
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- | Peeters N, Carrère S, Anisimova M, Plener L, Cazalé AC, Genin S (2013). Repertoire, unified nomenclature and evolution of the type III effector gene set in the //Ralstonia solanacearum// | ||
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- | Studholme DJ, Kemen E, MacLean D, Schornack S, Aritua V, Thwaites R, Grant M, Smith J, Jones JD (2010). Genome-wide sequencing data reveals virulence factors implicated in banana // | ||
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- | Teper D, Burstein D, Salomon D, Gershovitz M, Pupko T, Sessa G (2016). Identification of novel // | ||
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- | Vicente JG, Rothwell S, Holub EB, Studholme DJ (2017). Pathogenic, phenotypic and molecular characterisation of // | ||
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- | Wasukira A, Tayebwa J, Thwaites R, Paszkiewicz K, Aritua V, Kubiriba J, Smith J, Grant M, Studholme DJ (2012). Genome-wide sequencing reveals two major sub-lineages in the genetically monomorphic pathogen // | ||