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bacteria:t3e:xopau [2020/04/09 17:24] jfpothier |
bacteria:t3e:xopau [2020/07/03 09:57] rkoebnik |
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====== XopAU ====== | ====== XopAU ====== | ||
- | Author: Eran Bosis\\ | + | Author: |
- | Reviewer:\\ | + | Internal reviewer: [[https:// |
- | Expert reviewer: | + | Expert reviewer: |
Class: XopAU\\ | Class: XopAU\\ | ||
Family: XopAU\\ | Family: XopAU\\ | ||
- | Prototype: XopAU (// | + | Prototype: XopAU (// |
RefSeq ID: [[https:// | RefSeq ID: [[https:// | ||
3D structure: Unknown | 3D structure: Unknown | ||
Line 13: | Line 13: | ||
===== Biological function ===== | ===== Biological function ===== | ||
- | ==== How discovered? ==== | + | === How discovered? === |
- | XopAU was discovered using a machine-learning approach. REF :?: | + | |
- | ==== (Experimental) evidence for being a T3E ==== | + | XopAU was discovered using a machine-learning approach (Teper //et al//., 2016). |
- | XopAU fused to the AvrBs2 reporter, was shown to translocate into plant cells in an // | + | === (Experimental) evidence for being a T3E === |
- | ==== Regulation ==== | + | XopAU fused to the AvrBs2 reporter, was shown to translocate into plant cells in an //hrpF// |
- | XopAU homologs were shown to contain | + | === Regulation === |
- | ==== Phenotypes ==== | + | XopAU homologs were shown to contain the PIP-box motif in their promoter region (Teper //et al.//, 2018). XopAU from //X. citri// was found to be regulated by HrpG and HrpX (Guo //et al.//, 2011). |
- | // | + | === Phenotypes === |
+ | |||
+ | // | ||
+ | === Localization === | ||
- | ==== Localization ==== | ||
Unknown. | Unknown. | ||
- | ==== Enzymatic function ==== | + | === Enzymatic function === |
- | XopAU is an active protein kinase //in vitro// (Guo //et al//., 2011). | + | |
- | ==== Interaction partners ==== | + | XopAU is an active protein kinase |
- | XopAU was shown to interact with tomato MAPKK MKK2 and MAP kinases. Co-expression of XopAU and MKK2 in yeast caused a growth-inhibition phenotype. | + | === Interaction partners === |
+ | XopAU was shown to interact with tomato MAPKK MKK2 and MAP kinases. Co-expression of XopAU and MKK2 in yeast caused a growth-inhibition phenotype. XopAU was shown to phosphorylate MKK2 //in vitro// and to promote phosphorylation of MKK2 at multiple sites //in planta// (Teper //et al//., 2018). XopAU was shown to interact with tomato 14-3-3 (TFT) proteins (Dubrow //et al//., 2018). | ||
===== Conservation ===== | ===== Conservation ===== | ||
- | ==== In xanthomonads ==== | + | === In xanthomonads === |
- | Yes (//e.g.//, //X. fuscans, X. citri, X. oryzae, X. fragariae, X. avenae//: | + | |
- | ==== In other plant pathogens/ | + | Yes (//e.g.//, //X. fuscans, X. citri, X. oryzae, X. fragariae// |
- | Yes (// | + | === In other plant pathogens/ |
+ | Yes (// | ||
===== References ===== | ===== References ===== | ||
- | * Dubrow Z, Sunitha S, Kim JG, Aakre CD, Girija AM, Sobol G, Teper D, Chen YC, Ozbaki-Yagan N, Vance H, Sessa G, Mudgett MB (2018). Tomato 14-3-3 proteins are required for // | ||
- | * Guo Y, Figueiredo F, Jones J, Wang N (2011). HrpG and HrpX play global roles in coordinating different virulence traits of // | + | Dubrow Z, Sunitha S, Kim JG, Aakre CD, Girija AM, Sobol G, Teper D, Chen YC, Ozbaki-Yagan N, Vance H, Sessa G, Mudgett MB (2018). Tomato 14-3-3 proteins are required for //Xv3// disease resistance and interact with a subset of // |
+ | |||
+ | Guo Y, Figueiredo F, Jones J, Wang N (2011). HrpG and HrpX play global roles in coordinating different virulence traits of // | ||
- | * Teper D, Burstein D, Salomon D, Gershovitz M, Pupko T, Sessa G (2016). Identification of novel // | + | Teper D, Burstein D, Salomon D, Gershovitz M, Pupko T, Sessa G (2016). Identification of novel // |
- | * Teper D, Girija AM, Bosis E, Popov G, Savidor A, Sessa G (2018). The // | + | Teper D, Girija AM, Bosis E, Popov G, Savidor A, Sessa G (2018). The // |