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Bacterial virulence factors

Plant resistance genes

Molecular Diagnosis and Diversity for Regulated Xanthomonas

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This DokuWiki is based upon work from COST Action CA16107 EuroXanth, supported by COST (European Cooperation in Science and Technology)

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Author: Yael Helman
Internal reviewer: Monika Kałużna
Expert reviewer: FIXME

Class: XopAW
Family: XopAW
Prototype: XCV3093 (Xanthomonas euvesicatoria pv. euvesicatoria, ex Xanthomonas campestris pv. vesicatoria; strain 85-10)
RefSeq ID: CAJ24824.1 (221 aa)
3D structure: Unknown

Biological function

How discovered?

XopAW (XCV3093 in X. euvesicatoria 85-10; was discovered using a machine-learning approach; Teper et al., 2016).

(Experimental) evidence for being a T3E

XopAW fused to the AvrBs2 reporter, was shown to translocate into plant cells in an hrpF-dependent manner (Teper et al., 2016).




A Xanthomonas euvesicatoria 85-10 mutant defective in xopAW did not exhibit reduced virulence symptoms when inoculated on leaves of susceptible pepper plants, relative to wild-type 85-10 (Teper et al., 2016). Additionally, expression in Arabidopsis mesophyll protoplasts did not display any significant effect on suppression of the PTI-associated responses induced by the bacterial peptide flg22 (Popov et al., 2018).



Enzymatic function

XopAW contains a canonical EF-hand calcium-binding motif and can potentially interfere with host calcium signaling (Teper et al., 2016).

Interaction partners



In xanthomonads

Yes (e.g., X. arboricola, X. axonopodis, X. citri, X. euvesicatoria, X. phaseoli, all above 90% sequence identity; more distant homologs in X. hyacinthi, X. sacchari, X. translucens).

In other plant pathogens/symbionts

Yes (e.g., Ralstonia solanacearum, Acidovorax avenae, Pseudomonas syringae, Rhizobium) (Teper et al., 2016).


Popov G, Fraiture M, Brunner F, Sessa G (2018). Multiple Xanthomonas euvesicatoria type III effectors inhibit flg22-triggered immunity. Mol. Plant Microbe Interact. 29: 651-660. DOI: 10.1094/MPMI-07-16-0137-R

Teper D, Burstein D, Salomon D, Gershovitz M, Pupko T, Sessa G (2016). Identification of novel Xanthomonas euvesicatoria type III effector proteins by a machine-learning approach. Mol. Plant Pathol. 17: 398-411. DOI: 10.1111/mpp.12288

bacteria/t3e/xopaw.txt · Last modified: 2020/07/09 14:14 by rkoebnik