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bacteria:t3e:xopz [2020/07/02 16:08] rkoebnik [References] |
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- | ====== XopZ ====== | ||
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- | Author: Marlène Lachaux\\ | ||
- | Internal reviewer: FIXME \\ | ||
- | Expert reviewer: FIXME | ||
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- | Class: XopZ\\ | ||
- | Family: XopZ\\ | ||
- | Prototype: XopZ (// | ||
- | RefSeq ID: 1, | ||
- | ===== Biological function ===== | ||
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- | === How discovered? === | ||
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- | In 2009, generation of PXO99 mutants for 18 non-TAL T3 effector genes allowed to investigate the function of several T3Es in //Xoo// strain PXO99< | ||
- | === (Experimental) evidence for being a T3E === | ||
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- | With a PIP box upstream of the predicted translation start site // | ||
- | === Regulation === | ||
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- | The //XopZ// gene was shown to be expressed in a // | ||
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- | qRT-PCR revealed that transcript levels of 15 out of 18 tested non-TAL effector genes (as well as the regulatory genes //hrpG// and //hrpX//), including //xopZ//, were significantly reduced in the // | ||
- | === Phenotypes === | ||
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- | PXO99< | ||
- | === Localization === | ||
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- | XopZ< | ||
- | === Enzymatic function === | ||
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- | XopZ< | ||
- | === Interaction partners === | ||
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- | XopZ interacts with a putative host E3 ubiquitin ligase protein PBP (s-ribonuclease) //in vitro// and //in vivo//. Regions containing 193 aa - 225 aa of PBP is required for interacting with XopZ. PBP is a negative regulator of host immune response based on the disease phenotype in PBP-knockout rice plants. C1A directly interacts and strongly degrades PBP through its cysteine protease activity, leading to a homeostatic state of PBP in plant cells (Zhou //et al//., 2015). | ||
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- | ===== Conservation ===== | ||
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- | === In xanthomonads === | ||
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- | Yes, is found to be conserved in all // | ||
- | === In other plant pathogens/ | ||
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- | Related genes are also found in several // | ||
- | ===== References ===== | ||
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- | Liu Y, Long J, Shen D, Song C (2016). // | ||
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- | Ryan RP, Koebnik R, Szurek B, Boureau T, Bernal A, Bogdanove A, Dow JM (2009). Passing GO (gene ontology) in plant pathogen biology: a report from the // | ||
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- | Sinha D, Gupta MK, Patel HK, Ranjan A, Sonti RV (2013). Cell wall degrading enzyme induced rice innate immune responses are suppressed by the type 3 secretion system effectors XopN, XopQ, XopX and XopZ of // | ||
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- | Song C, Yang B (2010). Mutagenesis of 18 type III effectors reveals virulence function of XopZ < | ||
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- | Zhou H, Yang B (2018). Non-TAL effectors from // | ||
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- | Zhou J (2015). Host target genes of the // | ||