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bacteria:t3e:xopac [2020/08/11 14:50] rkoebnik [Biological function] |
bacteria:t3e:xopac [2020/11/29 07:29] jmzhouigdb [Biological function] |
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Author: [[https:// | Author: [[https:// | ||
- | Internal reviewer: | + | Internal reviewer: |
- | Expert reviewer: | + | Expert reviewer: |
Class: XopAC\\ | Class: XopAC\\ | ||
Family: XopAC\\ | Family: XopAC\\ | ||
- | Prototype: XopAC (// | + | Prototype: XopAC (// |
RefSeq ID: [[https:// | RefSeq ID: [[https:// | ||
3D structure: Unknown | 3D structure: Unknown | ||
+ | ===== Conservation ===== | ||
+ | |||
+ | === In xanthomonads === | ||
+ | |||
+ | xopAC is present in many //Xcc// strains as well as several // | ||
+ | === In other plant pathogens/ | ||
+ | |||
+ | Yes, //Ralstonia solanacearum// | ||
===== Biological function ===== | ===== Biological function ===== | ||
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=== (Experimental) evidence for being a T3E === | === (Experimental) evidence for being a T3E === | ||
- | The N-terminal region of XopAC (XopAC< | + | The N-terminal region of XopAC (XopAC< |
=== Regulation === | === Regulation === | ||
- | //xopAC// promoters possess a PIP-box motif (Xu //et al//., 2008). Expression of //xopAC// is induced in // | + | //xopAC// promoters possess a PIP-box motif (Xu //et al//., 2008). Expression of //xopAC// is induced in the // |
=== Phenotypes === | === Phenotypes === | ||
- | * //xopAC//, also named //avrAC//, confers avirulence to // | + | * //xopAC//, also named //avrAC//, confers avirulence to // |
* // | * // | ||
* // | * // | ||
* XopAC inhibits BIK1 kinase activity and blocks flg22-induced PTI responses (Feng //et al//., 2012). | * XopAC inhibits BIK1 kinase activity and blocks flg22-induced PTI responses (Feng //et al//., 2012). | ||
- | * XopAC was found to be associated with variations in disease symptoms when testing a set of 45 // | + | * XopAC was found to be associated with variations in disease symptoms when testing a set of 45 // |
- | * Mutagenesis of type III effectors in // | + | * Mutagenesis of type III effectors in // |
- | * When heterologously expressed in virulent //Ralstonia solanacearum// | + | * When heterologously expressed in virulent //Ralstonia solanacearum// |
- | * Transgenic expression of // | + | * Transgenic expression of // |
+ | * AvrAC recognition requires the RKS1 pseudokinase of the ZRK family and the NLR protein ZAR1, which also recognizes the // | ||
=== Localization === | === Localization === | ||
- | XopAC was localized to the plasma membrane upon // | + | XopAC was localized to the plant plasma membrane upon // |
=== Enzymatic function === | === Enzymatic function === | ||
- | XopAC presents an uridylyl transferase activity | + | XopAC presents an uridylyl transferase activity, which depends |
=== Interaction partners === | === Interaction partners === | ||
- | Nine // | + | Nine // |
===== Conservation ===== | ===== Conservation ===== | ||
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=== In xanthomonads === | === In xanthomonads === | ||
- | xopAC is present in many //Xcc// strains as well as several // | + | xopAC is present in many // |
=== In other plant pathogens/ | === In other plant pathogens/ | ||
- | Yes, //Ralstonia solanacearum// | + | Yes, //Ralstonia solanacearum// |
===== References ===== | ===== References ===== | ||
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Guy E, Lautier M, Chabannes M, Roux B, Lauber E, Arlat M, Noël LD (2013b). // | Guy E, Lautier M, Chabannes M, Roux B, Lauber E, Arlat M, Noël LD (2013b). // | ||
+ | |||
+ | Laflamme B, Dillon MM, Martel A, Almeida RND, Desveaux D, Guttman DS (2020). The pan-genome effector-triggered immunity ladscape of a host-pathogen interaction. Science 367: 763-768. [[http:// | ||
+ | |||
+ | Schultink A, Qi T, Bally J, Staskawicz B (2019). Using forward genetics in// Nicotiana benthamiana //to uncover the immune signaling pathway mediating recognition of the // | ||
Tan X, Qiu H, Li F, Cheng D, Zheng X, Wang B, Huang M, Li W, Li Y, Sang K, Song B, Du J, Chen H, Xie C (2019). Complete genome sequence of sequevar 14M //Ralstonia solanacearum// | Tan X, Qiu H, Li F, Cheng D, Zheng X, Wang B, Huang M, Li W, Li Y, Sang K, Song B, Du J, Chen H, Xie C (2019). Complete genome sequence of sequevar 14M //Ralstonia solanacearum// |