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--- bacteria:t3e:xopac [2020/08/11 14:59]
rkoebnik
+++ bacteria:t3e:xopac [2020/11/29 07:29] (current)
jmzhouigdb [Biological function]
@@ Line 3: / Line 3: @@
 Author: [[https://www.researchgate.net/profile/Laurent_Noel|Laurent D. Noël]]\\
 Internal reviewer: [[https://www.researchgate.net/profile/Ralf_Koebnik|Ralf Koebnik]]\\
-Expert reviewer: FIXME
+Expert reviewer: [[https://www.researchgate.net/profile/Jian-Min_Zhou|Jian-Min Zhou]]
 Class: XopAC\\
@@ Line 11: / Line 11: @@
 D structure: Unknown
+===== Conservation =====
+=== In xanthomonads ===
+xopAC is present in many //Xcc// strains as well as several //Xanthomonas campestris// pv. //raphani// (Guy //et al//., 2013a). To date, all allelic variants of XopAC conferred avirulence in //Arabidopsis// accession Col-0 (Guy //et al//., 2013b).
+=== In other plant pathogens/symbionts ===
+Yes, //Ralstonia solanacearum// (Tan //et al.//, 2019).
 ===== Biological function =====
@@ Line 28: / Line 36: @@
   * //xopAC//  contributes to //Xcc//  pathogenicity on //Brassica oleracea//  and //Arabidopsis//  in a //BIK1//-dependent manner (Feng //et al//., 2012).
   * XopAC inhibits BIK1 kinase activity and blocks flg22-induced PTI responses (Feng //et al//., 2012).
-  * XopAC was found to be associated with variations in disease symptoms when testing a set of 45 //Xcc// strains on two natural accessions of //Arabidopsis//  (Guy //et al.//, 2013a).
+  * XopAC was found to be associated with variations in disease symptoms when testing a set of 45 //Xcc//  strains on two natural accessions of //Arabidopsis//  (Guy //et al.//, 2013a).
   * Mutagenesis of type III effectors in //Xcc//  confirmed that //xopAC//  functions as both a virulence and an avirulence gene in //Arabidopsis//  (Guy et al., 2013).
   * When heterologously expressed in virulent //Ralstonia solanacearum//  or //Pseudomonas syringae//  pv. //tomato//, XopAC confers avirulence on the //Arabidopsis//  accession Col-0 (Guy //et al//., 2013b).
   * Transgenic expression of //xopAC//  in //Arabidopsis//  accession Col-0 induces early growth arrest at both apical and root meristems (Wang //et al//., 2015).
+  * AvrAC recognition requires the RKS1 pseudokinase of the ZRK family and the NLR protein ZAR1, which also recognizes the //Pseudomonas syringae//  effectors HopZ1a, HopBA1, HopF1, HopO1, and HopX1 and the //Xanthomonas perforans//effector XopJ4 (Wang //et al.//, 2015; Laflamme //et al., //2020; Schultink //et al., //2019).
 === Localization ===
@@ Line 39: / Line 48: @@
 === Enzymatic function ===
-XopAC presents an uridylyl transferase activity, which depends on residue H<sub>469</sub>  (Feng //et al//., 2012). XopAC is able to uridylylate both conserved S<sub>236</sub>  and T<sub>237</sub>  in BIK1. Similar activity was demonstrated for all other RLCK VIIa tested including PBL2 (Feng //et al//., 2012; Wang //et al//., 2015).
+XopAC presents an uridylyl transferase activity, which depends on residue H<sub>469</sub>  (Feng //et al//., 2012). XopAC is able to uridylylate both conserved S<sub>236</sub>  and T<sub>237</sub>  in BIK1. Similar activity was demonstrated for all other RLCK VIIa tested including PBL2, which acts as a decoy and enables AvrAC detection (Feng //et al//., 2012; Wang //et al//., 2015).
 === Interaction partners ===
@@ Line 57: / Line 66: @@
 ===== References =====
-Cerutti A, Jauneau A, Auriac M-C, Lauber E, Martinez Y, Chiarenza S, Leonhardt N, Berthomé R, Noël LD (2017). Immunity at cauliflower hydathodes controls infection by //Xanthomonas campestris//  pv. //campestris//. Plant Physiol. 174: 700-712. DOI: [[https://doi.org/10.1104/pp.16.01852|10.1104/pp.16.01852]]
+Cerutti A, Jauneau A, Auriac M-C, Lauber E, Martinez Y, Chiarenza S, Leonhardt N, Berthomé R, Noël LD (2017). Immunity at cauliflower hydathodes controls infection by //Xanthomonas campestris// pv. //campestris//. Plant Physiol. 174: 700-712. DOI: [[https://doi.org/10.1104/pp.16.01852|10.1104/pp.16.01852]]
+Feng F, Yang F, Rong W, Wu X, Zhang J, Chen S, He C, Zhou JM (2012). A //Xanthomonas// uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature 485: 114-118. DOI: [[https://doi.org/10.1038/nature10962|10.1038/nature10962]]
+Guy E, Genissel A, Hajri A, Chabannes M, David P, Carrère S, Lautier M, Roux B, Boureau T, Arlat M, Poussier S, Noël LD (2013a). Natural genetic variation of //Xanthomonas campestris// pv. campestris pathogenicity on //Arabidopsis// revealed by association and reverse genetics. MBio 4: e00538-12. DOI: [[https://doi.org/10.1128/mBio.00538-12|10.1128/mBio.00538-12]]. Erratum in: MBio (2013) 4: e00978-13.
-Feng F, Yang F, Rong W, Wu X, Zhang J, Chen S, He C, Zhou JM (2012). A //Xanthomonas//  uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature 485: 114-118. DOI: [[https://doi.org/10.1038/nature10962|10.1038/nature10962]]
+Guy E, Lautier M, Chabannes M, Roux B, Lauber E, Arlat M, Noël LD (2013b). //xopAC//-triggered immunity against //Xanthomonas// depends on //Arabidopsis// receptor-like cytoplasmic kinase genes //PBL2// and //RIPK//. PLoS One 8: e73469. DOI: [[https://doi.org/10.1371/journal.pone.0073469|10.1371/journal.pone.0073469]]
-Guy E, Genissel A, Hajri A, Chabannes M, David P, Carrère S, Lautier M, Roux B, Boureau T, Arlat M, Poussier S, Noël LD (2013a). Natural genetic variation of //Xanthomonas campestris//  pv. campestris pathogenicity on //Arabidopsis//  revealed by association and reverse genetics. MBio 4: e00538-12. DOI: [[https://doi.org/10.1128/mBio.00538-12|10.1128/mBio.00538-12]]. Erratum in: MBio (2013) 4: e00978-13.
+Laflamme B, Dillon MM, Martel A, Almeida RND, Desveaux D, Guttman DS (2020). The pan-genome effector-triggered immunity ladscape of a host-pathogen interaction. Science 367: 763-768. [[http://doi.org/10.1126/science.aax4079|http://doi.org/10.1126/science.aax4079]]
-Guy E, Lautier M, Chabannes M, Roux B, Lauber E, Arlat M, Noël LD (2013b). //xopAC//-triggered immunity against //Xanthomonas//  depends on //Arabidopsis//  receptor-like cytoplasmic kinase genes //PBL2//  and //RIPK//. PLoS One 8: e73469. DOI: [[https://doi.org/10.1371/journal.pone.0073469|10.1371/journal.pone.0073469]]
+Schultink A, Qi T, Bally J, Staskawicz B (2019). Using forward genetics in// Nicotiana benthamiana //to uncover the immune signaling pathway mediating recognition of the //Xanthomonas perforans //effector XopJ4. New Phytol. 221: 1001-1009. [[http://doi.org/doi: 10.1111/nph.15411|http://doi.org/doi: 10.1111/nph.15411]]
-Tan X, Qiu H, Li F, Cheng D, Zheng X, Wang B, Huang M, Li W, Li Y, Sang K, Song B, Du J, Chen H, Xie C (2019). Complete genome sequence of sequevar 14M //Ralstonia solanacearum//  strain HA4-1 reveals novel type III effectors acquired through horizontal gene transfer. Front. Microbiol. 10: 1893. DOI: [[https://doi.org/10.3389/fmicb.2019.01893|10.3389/fmicb.2019.01893]]
+Tan X, Qiu H, Li F, Cheng D, Zheng X, Wang B, Huang M, Li W, Li Y, Sang K, Song B, Du J, Chen H, Xie C (2019). Complete genome sequence of sequevar 14M //Ralstonia solanacearum// strain HA4-1 reveals novel type III effectors acquired through horizontal gene transfer. Front. Microbiol. 10: 1893. DOI: [[https://doi.org/10.3389/fmicb.2019.01893|10.3389/fmicb.2019.01893]]
 Wang G, Roux B, Feng F, Guy E, Li L, Li N, Zhang X, Lautier M, Jardinaud MF, Chabannes M, Arlat M, Chen S, He C, Noël LD, J.M. Zhou JM (2015). The decoy substrate of a pathogen effector and a pseudokinase specify pathogen-induced modified-self recognition and immunity in plants. Cell Host Microbe 18: 285-295. DOI: [[https://doi.org/10.1016/j.chom.2015.08.004|10.1016/j.chom.2015.08.004]]
-Xu RQ, Blanvillain S, Feng JX, Jiang BL, Li XZ, Wei HY, Kroj T, Lauber E, Roby D, Chen B, He YQ, Lu GT, Tang DJ, Vasse J, Arlat M, Tang JL (2008). AvrAC<sub>Xcc8004</sub>, a type III effector with a leucine-rich repeat domain from //Xanthomonas campestris//  pathovar //campestris//  confers avirulence in vascular tissues of //Arabidopsis//  //thaliana//  ecotype Col-0. J. Bacteriol. 190: 343-355. DOI: [[https://doi.org/10.1128/JB.00978-07|10.1128/JB.00978-07]]
+Xu RQ, Blanvillain S, Feng JX, Jiang BL, Li XZ, Wei HY, Kroj T, Lauber E, Roby D, Chen B, He YQ, Lu GT, Tang DJ, Vasse J, Arlat M, Tang JL (2008). AvrAC<sub>Xcc8004</sub>, a type III effector with a leucine-rich repeat domain from //Xanthomonas campestris// pathovar //campestris// confers avirulence in vascular tissues of //Arabidopsis// //thaliana// ecotype Col-0. J. Bacteriol. 190: 343-355. DOI: [[https://doi.org/10.1128/JB.00978-07|10.1128/JB.00978-07]]

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