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bacteria:t3e:xopp [2020/07/17 10:36]
rkoebnik [Biological function] 		bacteria:t3e:xopp [2022/06/23 09:53]
rkoebnik [Biological function]
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   * XopP<sub>Xoo</sub>  is able to suppress rice pathogen associated molecular pattern (PAMP)-immunity and resistance to //Xanthomonas oryzae//  pv. //oryzae//. Although XopP<sub>Xoo</sub>  is classified within the XopP, it shows only 40% sequence identity with the XopP homologue of //X. campestris//  pv. //campestris//  (Furutani //et al//., 2009). Therefore, it remains unclear if such interaction is similar in different pathosystems where XopP has been found.   * XopP<sub>Xoo</sub>  is able to suppress rice pathogen associated molecular pattern (PAMP)-immunity and resistance to //Xanthomonas oryzae//  pv. //oryzae//. Although XopP<sub>Xoo</sub>  is classified within the XopP, it shows only 40% sequence identity with the XopP homologue of //X. campestris//  pv. //campestris//  (Furutani //et al//., 2009). Therefore, it remains unclear if such interaction is similar in different pathosystems where XopP has been found.
   * //Agrobacterium//-mediated transient expression of both XopQ and XopX in rice cells resulted in induction of rice immune responses, which were not observed when either protein was individually expressed. A screen for //Xanthomonas//  effectors which can suppress XopQ-XopX induced rice immune responses, led to the identification of five effectors, namely XopU, XopV, XopP, XopG and AvrBs2, that could individually suppress these immune responses. These results suggest a complex interplay of //Xanthomonas//  T3SS effectors in suppression of both pathogen-triggered immunity and effector-triggered immunity to promote virulence on rice (Deb //et al.//, 2020).   * //Agrobacterium//-mediated transient expression of both XopQ and XopX in rice cells resulted in induction of rice immune responses, which were not observed when either protein was individually expressed. A screen for //Xanthomonas//  effectors which can suppress XopQ-XopX induced rice immune responses, led to the identification of five effectors, namely XopU, XopV, XopP, XopG and AvrBs2, that could individually suppress these immune responses. These results suggest a complex interplay of //Xanthomonas//  T3SS effectors in suppression of both pathogen-triggered immunity and effector-triggered immunity to promote virulence on rice (Deb //et al.//, 2020).
 +  * XopP inhibits the function of the host-plant exocyst complex by direct targeting of Exo70B, a subunit of the exocyst complex, which plays a significant role in plant immunity. XopP interferes with exocyst-dependent exocytosis, and can do this without activating a plant NLR (NOD-like receptor) that guards Exo70B in Arabidopsis. In this way, //Xanthomonas//  efficiently inhibits the host's pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) by blocking exocytosis of pathogenesis-related protein-1A (PR1a), callose deposition and localization of the FLS2 immune receptor to the plasma membrane, thus promoting successful infection (Michalopoulou //et al.//, 2022).
 +
 === Localization === === Localization ===
  
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 === Interaction partners === === Interaction partners ===
  
-XopP<sub>Xoo</sub>  interacts with the U-box domain of a rice ubiquitin E3 ligase, OsPUB44 and inhibits its activity (Ishikawa //et al//., 2014).+XopP<sub>Xoo</sub>  interacts with the U-box domain of a rice ubiquitin E3 ligase, OsPUB44 and inhibits its activity (Ishikawa //et al//., 2014). XopP interacts with EXO70B1 in a yeast two-hybrid assay and in planta, as assessed by split YFP and coIP assays (Michalopoulou //et al.//, 2022).
  
 ===== Conservation ===== ===== Conservation =====
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 Liu Y, Long J, Shen D, Song C (2016). //Xanthomonas oryzae// pv. //oryzae// requires H-NS-family protein XrvC to regulate virulence during rice infection. FEMS Microbiol. Lett. 363: fnw067. DOI: [[https://doi.org/10.1093/femsle/fnw067|10.1093/femsle/fnw067]] Liu Y, Long J, Shen D, Song C (2016). //Xanthomonas oryzae// pv. //oryzae// requires H-NS-family protein XrvC to regulate virulence during rice infection. FEMS Microbiol. Lett. 363: fnw067. DOI: [[https://doi.org/10.1093/femsle/fnw067|10.1093/femsle/fnw067]]
 +
 +Michalopoulou VA, Mermigka G, Kotsaridis K, Mentzelopoulou A, Celie PHN, Moschou PN, Jones JDG, Sarris PF (2022). The host exocyst complex is targeted by a conserved bacterial type-III effector that promotes virulence. Plant Cell, in press. DOI: [[https://doi.org/10.1093/plcell/koac162|10.1093/plcell/koac162]]
  
 Roden JA, Belt B, Ross JB, Tachibana T, Vargas J, Mudgett MB (2004). A genetic screen to isolate type III effectors translocated into pepper cells during //Xanthomonas// infection. Proc. Natl. Acad. Sci. USA 101: 16624-16629. DOI: [[https://doi.org/10.1073/pnas.0407383101|10.1073/pnas.0407383101]] Roden JA, Belt B, Ross JB, Tachibana T, Vargas J, Mudgett MB (2004). A genetic screen to isolate type III effectors translocated into pepper cells during //Xanthomonas// infection. Proc. Natl. Acad. Sci. USA 101: 16624-16629. DOI: [[https://doi.org/10.1073/pnas.0407383101|10.1073/pnas.0407383101]]
  
bacteria/t3e/xopp.txt ยท Last modified: 2022/06/23 09:55 by rkoebnik

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