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bacteria:t3e:xopx [2020/07/02 17:32] rkoebnik [Conservation] |
bacteria:t3e:xopx [2021/01/05 17:26] rkoebnik [Biological function] |
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====== XopX ====== | ====== XopX ====== | ||
- | Author: Lucas Morinière\\ | + | Author: |
- | Internal reviewer: | + | Internal reviewer: |
- | Expert reviewer: | + | Expert reviewer: |
Class: XopX\\ | Class: XopX\\ | ||
Family: XopX\\ | Family: XopX\\ | ||
- | Prototype: XopX (// | + | Prototype: XopX (// |
RefSeq ID: [[https:// | RefSeq ID: [[https:// | ||
3D structure: Unknown | 3D structure: Unknown | ||
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=== How discovered? === | === How discovered? === | ||
- | XopX was discovered through the screening of a genomic cosmid library of //X. euvesicatoria// | + | XopX was discovered through the screening of a genomic cosmid library of //X. euvesicatoria// |
=== (Experimental) evidence for being a T3E === | === (Experimental) evidence for being a T3E === | ||
Line 24: | Line 24: | ||
=== Phenotypes === | === Phenotypes === | ||
- | XopX was demonstrated to be cytotoxic when expressed in yeast, suggesting it may target a conserved eukaryotic cell process required for cell viability (Salomon //et al//., 2011). | + | * XopX was demonstrated to be cytotoxic when expressed in yeast, suggesting it may target a conserved eukaryotic cell process required for cell viability (Salomon //et al//., 2011). |
+ | * During infection of rice <font 10.5pt/ | ||
+ | * XopX is required for the development of //X. euvesicatoria// | ||
+ | * <font 10.5pt/ | ||
+ | * When expressed in // | ||
+ | * When transiently expressed in //N. benthamiana by Agrobacterium tumefaciens// | ||
+ | * //A ∆xopX// | ||
+ | * // | ||
+ | * A screen for // | ||
+ | * <font 10.5pt/ | ||
+ | * <font 10.5pt/ | ||
+ | * <font 10.5pt/ | ||
- | During infection of rice (//Oryzae sativa//) with //X. oryzae// pv. //oryzae//, XopX was shown to be an inhibitor of rice innate immune response, as it suppresses LipA-induced callose deposition (Sinha //et al//., 2013). | ||
- | |||
- | XopX is required for the development of //X. euvesicatoria// | ||
- | |||
- | Eventually, the complex behavior of XopX //in planta//, which combines activation and suppression of immunity-related plant responses at the same time, allows to classify this effector with the T3Es that activates the plant ‘default to death and defense’ response (Lindeberg //et al//., 2012; Stork //et al//., 2015). | ||
- | |||
- | A ∆//xopK// mutant strain of // | ||
=== Localization === | === Localization === | ||
- | Unknown. | + | // |
=== Enzymatic function === | === Enzymatic function === | ||
Line 43: | Line 47: | ||
=== Interaction partners === | === Interaction partners === | ||
- | It has been suggested that XopX-triggering of plant cell death response was dependent | + | * It has been suggested that XopX-triggering of plant cell death response was dependent |
+ | * <font 10.5pt/ | ||
+ | * <font 10.5pt/ | ||
- | ===== Conservation | + | === Conservation === |
- | === In xanthomonads | + | **In xanthomonads** |
- | Yes, //xopX// homologs can be found in almost every sequenced // | + | Yes, xopX homologs can be found in almost every sequenced // |
- | === In other plant pathogens/ | + | |
- | Related proteins (query cover > 80% and percent identity > 50 %) can be detected in several unclassified | + | **In other plant pathogens/symbionts ** |
- | ===== References ===== | + | Related proteins (query cover > 80% and percent identity > 50 %) can be detected in several unclassified Burkholderiales (// |
- | Lindeberg M, Cunnac S, Collmer A (2012). // | + | === References === |
- | Liu Y, Long J, Shen D, Song C (2016). //Xanthomonas | + | Deb S, Ghosh P, Patel HK, Sonti RV (2020). Interaction of the Xanthomonas |
- | Metz M, Dahlbeck D, Morales CQ, Sady BA, Clark ET, Staskawicz BJ (2005). The conserved // | + | Li S, Wang Y, Wang S, Fang A, Wang J, Liu L, Zhang K, Mao Y, Sun W (2015). The type III effector AvrBs2 in // |
+ | |||
+ | Liu Y, Long J, Shen D, Song C (2016). // | ||
+ | |||
+ | Medina CA, Reyes PA, Trujillo CA, Gonzalez JL, Bejarano DA, Montenegro NA, Jacobs JM, Joe A, Restrepo S, Alfano JR, Bernal A (2018). The role of type III effectors from // | ||
+ | |||
+ | Metz M, Dahlbeck D, Morales CQ, Sady BA, Clark ET, Staskawicz BJ (2005). The conserved// Xanthomonas campestris// | ||
Mutka AM, Fentress SJ, Sher JW, Berry JC, Pretz C, Nusinow DA, Bart R (2016). Quantitative, | Mutka AM, Fentress SJ, Sher JW, Berry JC, Pretz C, Nusinow DA, Bart R (2016). Quantitative, | ||
- | Salomon D, Dar D, Sreeramulu S, Sessa G (2011). Expression of // | + | Salomon D, Dar D, Sreeramulu S, Sessa G (2011). Expression of // |
+ | |||
+ | Sinha D, Gupta MK, Patel HK, Ranjan A, Sonti RV (2013). Cell wall degrading enzyme induced rice innate immune responses are suppressed by the type 3 secretion system effectors XopN, XopQ, XopX and XopZ of // | ||
- | Sinha D, Gupta MK, Patel HK, Ranjan A, Sonti RV (2013). Cell wall degrading enzyme induced rice innate immune responses are suppressed by the type 3 secretion system effectors XopN, XopQ, XopX and XopZ of // | + | <font 10.5pt/ |
- | Stork W, Kim JG, Mudgett MB (2015). Functional analysis of plant defense suppression and activation by the //Xanthomonas// core type III effector XopX. Mol. Plant. Microbe Interact. 28: 180-194. DOI: [[https:// | + | Stork W, Kim JG, Mudgett MB (2015). Functional analysis of plant defense suppression and activation by the Xanthomonas core type III effector XopX. Mol. Plant. Microbe Interact. 28: 180-194. DOI: [[https:// |