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--- bacteria:t3e:xopaw [2020/06/23 17:24]
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-====== XopAW ======
-Author: Yael Helman\\
-Internal reviewer: Monika Kałużna\\
-Expert reviewer:FIXME
-[[https://www.ncbi.nlm.nih.gov/protein/CAJ24824.1|Class: XopAW\\ Family: XopAW\\ Prototype: XopAW (XCV3093; //Xanthomonas euvesicatoria// pv. //euvesicatoria// aka //Xanthomonas campestris// pv. //vescicatoria//; strain 85-10)\\ RefSeq ID: CAJ24824.1]] (221 aa)\\
-D structure: Unknown
-===== Biological function =====
-=== How discovered? ===
-XopAW (XCV3093 in //X. euvesicatoria// 85-10 (was discovered using a machine-learning approach (Teper //et al//., 2016).
-=== (Experimental) evidence for being a T3E ===
-XopAW fused to the AvrBs2 reporter, was shown to translocate into plant cells in an //hrpF//-dependent manner (Teper //et al//., 2016).
-=== Regulation ===
-Unknown.
-=== Phenotypes ===
-A //Xanthomonas euvesicatoria// 85-10 mutant defective in //xopAW// did not exhibit reduced virulence symptoms when inoculated on leaves of susceptible pepper plants, relative to wild-type 85-10 (Teper //et al//., 2016). Additionally, expression in //Arabidopsis// mesophyll protoplasts did not lead to the suppression of the PTI-associated responses induced by the bacterial peptide flg22 (Popov //et al//., 2018).
-=== Localization ===
-Unknown.
-=== Enzymatic function ===
-XopAW contains a canonical EF-hand calcium-binding motif and can potentially interfere with host calcium signaling (Teper //et al//., 2016).
-=== Interaction partners ===
-Unknown.
-===== Conservation =====
-=== In xanthomonads ===
-Yes (//e.g.//, //X//. //perforans//, //X//. axonopodis//, //X//. //citri//, //X//. //arboricola//, //X//. //phaseoli//, //X//. //campestris//, //X//. //sacchari//, //X//. //hyacinthi//). //
-**In other plant pathogens/symbionts**
-//Yes (//e.g.//, Ralstonia solanacearum, Acidovorax avenae, Pseudomonas syringae, Rhizobium//)(//Teper //et al//., 2016). //
-<font 18px/inherit;;inherit;;inherit>**References**</font>[[https://doi.org/10.1094/MPMI-07-16-0137-R|Popov G, Fraiture M, Brunner F, Sessa G (2018). Multiple //Xanthomonas euvesicatoria// type III effectors inhibit flg22-triggered immunity. Mol. Plant-Microbe Interact. 29(8):651-660. DOI: 10.1094/MPMI-07-16-0137-R]].
-Teper D, Burstein D, Salomon D, Gershovitz M, Pupko T, Sessa G (2016). Identification of novel //Xanthomonas euvesicatoria// type III effector proteins by a machine-learning approach. Mol. Plant Pathol. 17(3): 398-411. DOI: [[https://doi.org/10.1111/mpp.12288|10.1111/mpp.12288]]. // //

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