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bacteria:t3e:xopac [2020/08/09 18:18] rkoebnik [Biological function] |
bacteria:t3e:xopac [2020/11/29 07:29] (current) jmzhouigdb [Biological function] |
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Author: [[https:// | Author: [[https:// | ||
- | Internal reviewer: | + | Internal reviewer: |
- | Expert reviewer: | + | Expert reviewer: |
Class: XopAC\\ | Class: XopAC\\ | ||
Family: XopAC\\ | Family: XopAC\\ | ||
- | Prototype: XopAC (// | + | Prototype: XopAC (// |
RefSeq ID: [[https:// | RefSeq ID: [[https:// | ||
3D structure: Unknown | 3D structure: Unknown | ||
+ | ===== Conservation ===== | ||
+ | |||
+ | === In xanthomonads === | ||
+ | |||
+ | xopAC is present in many //Xcc// strains as well as several // | ||
+ | === In other plant pathogens/ | ||
+ | |||
+ | Yes, //Ralstonia solanacearum// | ||
===== Biological function ===== | ===== Biological function ===== | ||
=== How discovered? === | === How discovered? === | ||
- | XopAC/AvrAC was identified as a putative type III effector because of the presence of seven prokaryotic-type leucine-rich repeats in its C-terminal domain and a PIP-box motif in //xopAC// promoter suggestive of a // | + | XopAC/AvrAC was identified as a putative type III effector because of the presence of seven prokaryotic-type leucine-rich repeats in its C-terminal domain and a PIP-box motif in the //xopAC// promoter suggestive of a // |
=== (Experimental) evidence for being a T3E === | === (Experimental) evidence for being a T3E === | ||
- | The first XopAC< | + | The N-terminal region of XopAC (XopAC< |
=== Regulation === | === Regulation === | ||
- | //xopAC// promoters possess a PIP-box motif (Xu //et al//., 2008). Expression of //xopAC// is induced in // | + | //xopAC// promoters possess a PIP-box motif (Xu //et al//., 2008). Expression of //xopAC// is induced in the // |
=== Phenotypes === | === Phenotypes === | ||
- | * //xopAC//, also named //avrAC//, confers avirulence to // | + | * //xopAC//, also named //avrAC//, confers avirulence to // |
* // | * // | ||
* // | * // | ||
* XopAC inhibits BIK1 kinase activity and blocks flg22-induced PTI responses (Feng //et al//., 2012). | * XopAC inhibits BIK1 kinase activity and blocks flg22-induced PTI responses (Feng //et al//., 2012). | ||
- | * XopAC was found to be associated with variations in disease symptoms when testing a set of 45 // | + | * XopAC was found to be associated with variations in disease symptoms when testing a set of 45 // |
- | * Mutagenesis of type III effectors in // | + | * Mutagenesis of type III effectors in // |
- | * When heterologously expressed in virulent //Ralstonia solanacearum// | + | * When heterologously expressed in virulent //Ralstonia solanacearum// |
- | * Transgenic expression of // | + | * Transgenic expression of // |
+ | * AvrAC recognition requires the RKS1 pseudokinase of the ZRK family and the NLR protein ZAR1, which also recognizes the // | ||
=== Localization === | === Localization === | ||
- | XopAC was localized to the plasma membrane upon // | + | XopAC was localized to the plant plasma membrane upon // |
=== Enzymatic function === | === Enzymatic function === | ||
- | XopAC presents an uridylyl transferase activity | + | XopAC presents an uridylyl transferase activity, which depends |
=== Interaction partners === | === Interaction partners === | ||
- | Nine // | + | Nine // |
===== Conservation ===== | ===== Conservation ===== | ||
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=== In xanthomonads === | === In xanthomonads === | ||
- | xopAC is present in many //Xcc// strains as well as several // | + | xopAC is present in many // |
=== In other plant pathogens/ | === In other plant pathogens/ | ||
- | No. | + | Yes, //Ralstonia solanacearum// |
===== References ===== | ===== References ===== | ||
- | Cerutti A, Jauneau A, Auriac M-C, Lauber E, Martinez Y, Chiarenza S, Leonhardt N, Berthomé R, Noël LD (2017). Immunity at cauliflower hydathodes controls infection by // | + | Cerutti A, Jauneau A, Auriac M-C, Lauber E, Martinez Y, Chiarenza S, Leonhardt N, Berthomé R, Noël LD (2017). Immunity at cauliflower hydathodes controls infection by // |
+ | |||
+ | Feng F, Yang F, Rong W, Wu X, Zhang J, Chen S, He C, Zhou JM (2012). A // | ||
+ | |||
+ | Guy E, Genissel A, Hajri A, Chabannes M, David P, Carrère S, Lautier M, Roux B, Boureau T, Arlat M, Poussier S, Noël LD (2013a). Natural genetic variation of // | ||
+ | |||
+ | Guy E, Lautier M, Chabannes M, Roux B, Lauber E, Arlat M, Noël LD (2013b). // | ||
- | Feng F, Yang F, Rong W, Wu X, Zhang J, Chen S, He C, Zhou JM (2012). A // | + | Laflamme B, Dillon MM, Martel A, Almeida RND, Desveaux D, Guttman DS (2020). The pan-genome effector-triggered immunity ladscape of a host-pathogen interaction. Science 367: 763-768. [[http:// |
- | Guy E, Genissel | + | Schultink |
- | Guy E, Lautier M, Chabannes | + | Tan X, Qiu H, Li F, Cheng D, Zheng X, Wang B, Huang M, Li W, Li Y, Sang K, Song B, Du J, Chen H, Xie C (2019). Complete genome sequence of sequevar 14M //Ralstonia solanacearum// strain HA4-1 reveals novel type III effectors acquired through horizontal gene transfer. Front. Microbiol. 10: 1893. DOI: [[https:// |
Wang G, Roux B, Feng F, Guy E, Li L, Li N, Zhang X, Lautier M, Jardinaud MF, Chabannes M, Arlat M, Chen S, He C, Noël LD, J.M. Zhou JM (2015). The decoy substrate of a pathogen effector and a pseudokinase specify pathogen-induced modified-self recognition and immunity in plants. Cell Host Microbe 18: 285-295. DOI: [[https:// | Wang G, Roux B, Feng F, Guy E, Li L, Li N, Zhang X, Lautier M, Jardinaud MF, Chabannes M, Arlat M, Chen S, He C, Noël LD, J.M. Zhou JM (2015). The decoy substrate of a pathogen effector and a pseudokinase specify pathogen-induced modified-self recognition and immunity in plants. Cell Host Microbe 18: 285-295. DOI: [[https:// | ||
- | Xu RQ, Blanvillain S, Feng JX, Jiang BL, Li XZ, Wei HY, Kroj T, Lauber E, Roby D, Chen B, He YQ, Lu GT, Tang DJ, Vasse J, Arlat M, Tang JL (2008). AvrAC< | + | Xu RQ, Blanvillain S, Feng JX, Jiang BL, Li XZ, Wei HY, Kroj T, Lauber E, Roby D, Chen B, He YQ, Lu GT, Tang DJ, Vasse J, Arlat M, Tang JL (2008). AvrAC< |