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--- bacteria:t3e:xopaj [2022/06/22 13:56]
rkoebnik
+++ bacteria:t3e:xopaj [2022/06/22 14:01] (current)
rkoebnik [Biological function]
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+====== XopAJ ======
+Authors: [[https://www.researchgate.net/profile/Ralf_Koebnik|Ralf Koebnik]] & Trainees from the 2<sup>nd</sup>  EuroXanth Training School ([[https://www.researchgate.net/profile/Daiva_Burokiene|Daiva Burokienė]], [[https://www.researchgate.net/profile/ermic_Edyta|Edyta Đermić]], [[https://www.researchgate.net/profile/Dagmar_Stehlikova|Dagmar Stehlikova]], [[https://www.researchgate.net/profile/Mariya_Stoyanova|Mariya Stoyanova]])\\
+Internal reviewer: [[https://www.researchgate.net/profile/Joel_Pothier2|Joël F. Pothier]]\\
+Expert reviewer: [[https://www.researchgate.net/profile/Lindsay_Triplett|Lindsay Triplett]]
+Class: XopAJ\\
+Family: XopAJ\\
+Prototype: XopAJ (//Xanthomonas oryzae// pv. //oryzicola//; strain BLS256)\\
+RefSeq ID: [[https://www.ncbi.nlm.nih.gov/protein/WP_014504815.1|WP_014504815.1 ]] (obsolete version suggested to be replaced by [[https://www.ncbi.nlm.nih.gov/protein/WP_153816726.1|WP_153816726.1]]) (421 aa)\\
+Synonym: AvrRxo1\\
+D structure: [[https://www.rcsb.org/structure/4Z8Q|4Z8Q]], [[https://www.rcsb.org/structure/4Z8T|4Z8T]], [[https://www.rcsb.org/structure/4Z8U|4Z8U]], [[https://www.rcsb.org/structure/4Z8V|4Z8V]] (Han //et al.//, 2015)
 ====== XopAJ ======
@@ Line 58: / Line 70: @@
 AvrRxo1 interacts with the //Arabidopsis thaliana//  ubiquitin E3 ligase SINAT4 and the cysteine protease RD21A during transient expression in //N. benthamiana. //Interaction enhanced SINAT4 activity and promoted the degradation of RD21A //in vivo, //in a manner dependent on the AvrRxo1 ATP-binding motif (Liu //et al.//, 2020).
+AvrRxo1 interacts with OsPDX1.2 in a yeast two-hybrid assay and in planta, as assessed by split YFP and coIP assays (Liu //et al.//, 2022).
+===== Conservation =====
+=== In xanthomonads ===
+Yes (e.g. //X. alfalfae//, //X. axonopodis//, //X. bromi//, //X. euvesicatoria//, //X. oryzae//, //X. translucens//).
+AvrRxo1 appears to be widely conserved in Asian strains of //Xoc//  but much less present in African strains, which implies that deployment of //Rxo1//-containing varieties may not be an appropriate breeding strategy for controlling bacterial leaf streak disease in Africa (Wonni //et al.//, 2014).
+AvrRxo1 is conserved in nearly all strains of //X. euvesicatoria//, but is incompletely distributed in other species surveyed (Triplett et al. 2016, Barak et al. 2016). Strains with inactivated //avrRxo1//  genes were frequently observed to harbor sequence insertions in the toxic //avrRxo1//  gene, while the toxin-protective //arc1//  gene remained intact (Triplett //et al.,//  2016).
+=== In other plant pathogens/symbionts ===
+Yes (//Acidovorax//  spp., //Paraburkholderia andropogonis//) (Triplett //et al.//, 2016).
+Homologs of the //avrRxo1:arc1//  operon in which the avrRxo1 homolog lacks a type III secretion signal are found in other environmental microbes, including the filamentous myxobacteria //Cystobacter fuscus//  and uncultured candidate //Saccharimonas//  and //Parcubacteria//  spp. (Triplett// et al.//  2016).
 ===== Conservation =====
@@ Line 79: / Line 109: @@
 Bahadur RP, Basak J (2014). Molecular modeling of protein-protein interaction to decipher the structural mechanism of nonhost resistance in rice. J. Biomol. Struct. Dyn. 32: 669-681. DOI: [[https://doi.org/10.1080/07391102.2013.787370|10.1080/07391102.2013.787370]]
-Han Q, Zhou C, Wu S, Liu Y, Triplett L, Miao J, Tokuhisa J, Deblais L, Robinson H, Leach JE, Li J, Zhao B (2015). Crystal structure of //Xanthomonas//  AvrRxo1-ORF1, a type III effector with a polynucleotide kinase domain, and its interactor AvrRxo1-ORF2. Structure 23: 1900-1909. DOI: [[https://doi.org/10.1016/j.str.2015.06.030|10.1016/j.str.2015.06.030]]
+Han Q, Zhou C, Wu S, Liu Y, Triplett L, Miao J, Tokuhisa J, Deblais L, Robinson H, Leach JE, Li J, Zhao B (2015). Crystal structure of //Xanthomonas// AvrRxo1-ORF1, a type III effector with a polynucleotide kinase domain, and its interactor AvrRxo1-ORF2. Structure 23: 1900-1909. DOI: [[https://doi.org/10.1016/j.str.2015.06.030|10.1016/j.str.2015.06.030]]
 Liu H, Chang Q, Feng W, Zhang B, Wu T, Li N, Yao F, Ding X, Chu Z (2014). Domain dissection of AvrRxo1 for suppressor, avirulence and cytotoxicity functions. PLoS One 9: e113875. DOI: [[https://doi.org/10.1371/journal.pone.0113875|10.1371/journal.pone.0113875]]
-Liu Y, Wang K, Cheng Q, Kong D, Zhang X, Wang Z, Wang Q, Qi X, Yan J, Chu J, Ling H, Li Q, Miao J, Zhao B (2020). Cysteine protease RD21A regulated by E3 ligase SINAT4 is required for drought-induced resistance to //Pseudomonas syringae//  in Arabidopsis. J. Exp. Bot., eraa255 (in press). DOI: [[https://doi.org/10.1093/jxb/eraa255|10.1093/jxb/eraa255]]
+Liu H, Lu C, Li Y, Wu T, Zhang B, Liu B, Feng W, Xu Q, Dong H, He S, Chu Z, Ding X (2022). The bacterial effector AvrRxo1 inhibits vitamin B6 biosynthesis to promote infection in rice. Plant Commun. 3: 100324. DOI: [[https://doi.org/10.1016/j.xplc.2022.100324|10.1016/j.xplc.2022.100324]]
+Liu Y, Wang K, Cheng Q, Kong D, Zhang X, Wang Z, Wang Q, Qi X, Yan J, Chu J, Ling H, Li Q, Miao J, Zhao B (2020). Cysteine protease RD21A regulated by E3 ligase SINAT4 is required for drought-induced resistance to //Pseudomonas syringae// in Arabidopsis. J. Exp. Bot. 71: 5562-5576. DOI: [[https://doi.org/10.1093/jxb/eraa255|10.1093/jxb/eraa255]]
-Popov G, Fraiture M, Brunner F, Sessa G (2016). Multiple //Xanthomonas euvesicatoria//  type III effectors inhibit flg22-triggered immunity. Mol. Plant Microbe Interact. 29: 651-660. DOI: [[https://doi.org/10.1094/MPMI-07-16-0137-R|10.1094/MPMI-07-16-0137-R]]
+Popov G, Fraiture M, Brunner F, Sessa G (2016). Multiple //Xanthomonas euvesicatoria// type III effectors inhibit flg22-triggered immunity. Mol. Plant Microbe Interact. 29: 651-660. DOI: [[https://doi.org/10.1094/MPMI-07-16-0137-R|10.1094/MPMI-07-16-0137-R]]
-Salomon D, Dar D, Sreeramulu S, Sessa G (2011). Expression of //Xanthomonas////campestris//  pv. //vesicatoria//  type III effectors in yeast affects cell growth and viability. Mol. Plant Microbe Interact. 24: 305-314. DOI: [[https://doi.org/10.1094/MPMI-09-10-0196|10.1094/MPMI-09-10-0196]]
+Salomon D, Dar D, Sreeramulu S, Sessa G (2011). Expression of //Xanthomonas////campestris// pv. //vesicatoria// type III effectors in yeast affects cell growth and viability. Mol. Plant Microbe Interact. 24: 305-314. DOI: [[https://doi.org/10.1094/MPMI-09-10-0196|10.1094/MPMI-09-10-0196]]
 Schuebel F, Rocker A, Edelmann D, Schessner J, Brieke C, Meinhart A (2016). 3'-NADP and 3'-NAADP, two metabolites formed by the bacterial type III effector AvrRxo1. J. Biol. Chem. 291: 22868-22880. DOI: [[https://doi.org/10.1074/jbc.M116.751297|10.1074/jbc.M116.751297]]
@@ Line 95: / Line 127: @@
 Triplett LR, Shidore T, Long J, Miao J, Wu S, Han Q, Zhou C, Ishihara H, Li J, Zhao B, Leach JE (2016). AvrRxo1 Is a bifunctional type III secreted effector and toxin-antitoxin system component with homologs in diverse environmental contexts. PLoS One 11: e0158856. DOI: [[https://doi.org/10.1371/journal.pone.0158856|10.1371/journal.pone.0158856]]
-Wonni I, Cottyn B, Detemmerman L, Dao S, Ouedraogo L, Sarra S, Tekete C, Poussier S, Corral R, Triplett L, Koita O, Koebnik R, Leach J, Szurek B, Maes M, Verdier V (2014). Analysis of //Xanthomonas oryzae//  pv. //oryzicola//  population in Mali and Burkina Faso reveals a high level of genetic and pathogenic diversity. Phytopathology 104: 520-531. DOI: [[https://doi.org/10.1094/PHYTO-07-13-0213-R|10.1094/PHYTO-07-13-0213-R]]
+Wonni I, Cottyn B, Detemmerman L, Dao S, Ouedraogo L, Sarra S, Tekete C, Poussier S, Corral R, Triplett L, Koita O, Koebnik R, Leach J, Szurek B, Maes M, Verdier V (2014). Analysis of //Xanthomonas oryzae// pv. //oryzicola// population in Mali and Burkina Faso reveals a high level of genetic and pathogenic diversity. Phytopathology 104: 520-531. DOI: [[https://doi.org/10.1094/PHYTO-07-13-0213-R|10.1094/PHYTO-07-13-0213-R]]
-Wu S (2015). Structural and functional characterization of a //Xanthomonas//  type III effector. PhD dissertation. Link: [[https://vtechworks.lib.vt.edu/handle/10919/73219|https://vtechworks.lib.vt.edu/handle/10919/73219]]
+Wu S (2015). Structural and functional characterization of a //Xanthomonas// type III effector. PhD dissertation. Link: [[https://vtechworks.lib.vt.edu/handle/10919/73219|https://vtechworks.lib.vt.edu/handle/10919/73219]]
-Xie XW, Yu J, Xu JL, Zhou YL, Li ZK (2007). Introduction of a non-host gene //Rxo1//  cloned from maize resistant to rice bacterial leaf streak into rice varieties. Sheng Wu Gong Cheng Xue Bao [Chinese J. Biotechnol.] 23: 607-611. DOI: [[https://doi.org/10.1016/S1872-2075(07)60039-9|10.1016/S1872-2075(07)60039-9]]
+Xie XW, Yu J, Xu JL, Zhou YL, Li ZK (2007). Introduction of a non-host gene //Rxo1// cloned from maize resistant to rice bacterial leaf streak into rice varieties. Sheng Wu Gong Cheng Xue Bao [Chinese J. Biotechnol.] 23: 607-611. DOI: [[https://doi.org/10.1016/S1872-2075(07)60039-9|10.1016/S1872-2075(07)60039-9]]
-Zhao B, Ardales EY, Raymundo A, Bai J, Trick HN, Leach JE, Hulbert SH (2004). The //avrRxo1//  gene from the rice pathogen //Xanthomonas oryzae//  pv. //oryzicola//  confers a nonhost defense reaction on maize with resistance gene //Rxo1//. Mol. Plant Microbe Interact. 17: 771-779. DOI: [[https://doi.org/10.1094/MPMI.2004.17.7.771|10.1094/MPMI.2004.17.7.771]]
+Zhao B, Ardales EY, Raymundo A, Bai J, Trick HN, Leach JE, Hulbert SH (2004). The //avrRxo1// gene from the rice pathogen //Xanthomonas oryzae// pv. //oryzicola// confers a nonhost defense reaction on maize with resistance gene //Rxo1//. Mol. Plant Microbe Interact. 17: 771-779. DOI: [[https://doi.org/10.1094/MPMI.2004.17.7.771|10.1094/MPMI.2004.17.7.771]]
 Zhao B, Lin X, Poland J, Trick H, Leach J, Hulbert S (2005). A maize resistance gene functions against bacterial streak disease in rice. Proc. Natl. Acad. Sci. USA 102: 15383-15388. DOI: [[https://doi.org/10.1073/pnas.0503023102|10.1073/pnas.0503023102]]

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