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bacteria:t3e:xopau [2020/04/09 17:39] jfpothier [Biological function] |
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- | ====== XopAU ====== | ||
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- | Author: Eran Bosis\\ | ||
- | Reviewer:\\ | ||
- | Expert reviewer: | ||
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- | Class: XopAU\\ | ||
- | Family: XopAU\\ | ||
- | Prototype: XopAU (// | ||
- | RefSeq ID: [[https:// | ||
- | 3D structure: Unknown | ||
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- | ===== Biological function ===== | ||
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- | === How discovered? === | ||
- | XopAU was discovered using a machine-learning approach (Teper //et al//., 2016). | ||
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- | === (Experimental) evidence for being a T3E === | ||
- | XopAU fused to the AvrBs2 reporter, was shown to translocate into plant cells in an // | ||
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- | === Regulation === | ||
- | XopAU homologs were shown to contain the PIP-box motif in their promoter region. XopAU from //X. citri// was found to be regulated by HrpG and HrpX. | ||
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- | === Phenotypes === | ||
- | // | ||
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- | === Localization === | ||
- | Unknown. | ||
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- | === Enzymatic function === | ||
- | XopAU is an active protein kinase //in vitro// (Guo //et al//., 2011). | ||
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- | === Interaction partners === | ||
- | XopAU was shown to interact with tomato MAPKK MKK2 and MAP kinases. Co-expression of XopAU and MKK2 in yeast caused a growth-inhibition phenotype. XopAU was shown to phosphorylate MKK2 //in vitro// and to promote phosphorylation of MKK2 at multiple sites //in planta// (Guo //et al//., 2011). XopAU was shown to interact with tomato 14-3-3 (TFT) proteins (Teper //et al//., 2018). | ||
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- | ===== Conservation ===== | ||
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- | === In xanthomonads === | ||
- | Yes (//e.g.//, //X. fuscans, X. citri, X. oryzae, X. fragariae, X. avenae//: | ||
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- | === In other plant pathogens/ | ||
- | Yes (// | ||
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- | ===== References ===== | ||
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- | Dubrow Z, Sunitha S, Kim JG, Aakre CD, Girija AM, Sobol G, Teper D, Chen YC, Ozbaki-Yagan N, Vance H, Sessa G, Mudgett MB (2018). Tomato 14-3-3 proteins are required for // | ||
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- | Guo Y, Figueiredo F, Jones J, Wang N (2011). HrpG and HrpX play global roles in coordinating different virulence traits of // | ||
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- | Teper D, Burstein D, Salomon D, Gershovitz M, Pupko T, Sessa G (2016). Identification of novel // | ||
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- | Teper D, Girija AM, Bosis E, Popov G, Savidor A, Sessa G (2018). The // | ||